IRGM in autophagy and viral infections

IRGM in autophagy and viral infections

Autophagy is a cell autonomous process allowing each individual cell to fight intracellular pathogens. Autophagy can destroy pathogens within the cytosol, and can elicit innate and adaptive immune responses against microorganisms. Nevertheless, numerous pathogens have developed molecular strategies enabling them to avoid or even exploit autophagy for their own benefit. IRGM (immunity-related GT...

Studies on Avian Viral Infections in Iran

RNase L triggers autophagy in response to viral infections.

Autophagy is a programmed homeostatic response to diverse types of cellular stress that disposes of long-lived proteins, organelles, and invading microbes within double-membraned structures called autophagosomes. The 2',5'-oligoadenylate/RNase L system is a virus-activated host RNase pathway that disposes of or processes viral and cellular single-stranded RNAs. Here we report that activation of...

P-53: Chronic Viral Infections and Infertility in Male

Background: The most common sexually transmitted diseases and the economic and social health problem throughout the world. However, vaccine coverage and antibiotic therapy and the development of programs to prevent and control major causes of acute and chronic diseases, pregnancy complications and infertility remains. Acute and chronic systemic viral infections can lead to infertility and perma...

HLA-KIR Interactions and Immunity to Viral Infections

Host genetic factors play a central role in determining the clinical phenotype of human diseases. Association between two polymorphic loci in human genome, human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIRs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. Hence, defining the influence of genetic di...